gem ‐Bisphosphonate‐Ended Group Dendrimers: Design and Gadolinium Complexing Properties | Zendy

Franc Grégory | Zendy; Turrin CédricOlivier | Zendy; Cavero Emma | Zendy; Costes JeanPierre | Zendy; Duhayon Carine | Zendy; Caminade AnneMarie | Zendy; Majoral JeanPierre | Zendy

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gem ‐Bisphosphonate‐Ended Group Dendrimers: Design and Gadolinium Complexing Properties

Author(s) -

Franc Grégory,

Turrin CédricOlivier,

Cavero Emma,

Costes JeanPierre,

Duhayon Carine,

Caminade AnneMarie,

Majoral JeanPierre

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900458

Subject(s) - dendrimer , chemistry , bisphosphonate , chelation , nucleophilic substitution , nucleophile , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , osteoporosis , medicine , endocrinology

The synthesis of the first gem ‐bisphosphonate‐ended group dendrimers is described using nucleophilic substitution of terminal P(S)Cl 2 units of phosphorus dendrimers of generation 1 to 3 with protected aminophenols followed by deprotection of amino groups and Michael addition with vinylidene tetraisopropyl bisphosphonate. These dendrimers were found to act as chelating agents towards Gd ions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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