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gem ‐Bisphosphonate‐Ended Group Dendrimers: Design and Gadolinium Complexing Properties
Author(s) -
Franc Grégory,
Turrin CédricOlivier,
Cavero Emma,
Costes JeanPierre,
Duhayon Carine,
Caminade AnneMarie,
Majoral JeanPierre
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900458
Subject(s) - dendrimer , chemistry , bisphosphonate , chelation , nucleophilic substitution , nucleophile , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , osteoporosis , medicine , endocrinology
The synthesis of the first gem ‐bisphosphonate‐ended group dendrimers is described using nucleophilic substitution of terminal P(S)Cl 2 units of phosphorus dendrimers of generation 1 to 3 with protected aminophenols followed by deprotection of amino groups and Michael addition with vinylidene tetraisopropyl bisphosphonate. These dendrimers were found to act as chelating agents towards Gd ions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)