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N ‐Allylideneamines Derived from Acrolein: Synthesis and Use as Acceptors of Two Nucleophiles
Author(s) -
Mizota Isao,
Matsuda Yuri,
Hachiya Iwao,
Shimizu Makoto
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900457
Subject(s) - acrolein , chemistry , nucleophile , isomerization , dehydration , nucleophilic addition , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , biochemistry
Two practical methods have been developed for the preparation of N ‐allylideneamines 1b , c . One involves the isomerization of propargylamines and the other the dehydration of acrolein. N ‐Allylideneamines 1b , c thus prepared were used as efficient substrates for 1,4‐ and 1,2‐double nucleophilic addition reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)