Novel Antioxidant  neo ‐Clerodane Diterpenoids from  Scutellaria barbata | Zendy

Nguyen Van Hung | Zendy; Pham Van Cuong | Zendy; Nguyen Thi Thu Ha | Zendy; Tran Van Hieu | Zendy; Doan Thi Mai Huong | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Novel Antioxidant neo ‐Clerodane Diterpenoids from Scutellaria barbata

Author(s) -

Nguyen Van Hung,

Pham Van Cuong,

Nguyen Thi Thu Ha,

Tran Van Hieu,

Doan Thi Mai Huong

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900431

Subject(s) - chemistry , chirality (physics) , lamiaceae , scutellaria , stereochemistry , diterpene , absolute configuration , botany , traditional chinese medicine , quantum mechanics , pathology , medicine , physics , chiral symmetry breaking , alternative medicine , nambu–jona lasinio model , quark , biology

Four new neo ‐clerodane diterpenoids, barbatines A–D ( 1 – 4 ), have been isolated from the whole plant of Scutellariabarbata (Lamiaceae), along with the known scutebarbatine A ( 5 ), and their structures determined by spectral analysis, including mass spectrometry and 2D NMR spectroscopy. The absolute configurations of 2 and 5 were established from their CD spectra by using the exciton chirality rule. A biogenetic pathway for these compounds is proposed based on their structures. Barbatine A ( 1 ) and scutebarbatine A ( 5 ) showed a significant ability to protect cells against H 2 O 2 with ED 50 values of 16.8 and 5.0 μ M , respectively.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research