Asymmetric Addition of Terminal Alkynes to  N ‐(Diphenylphosphinoyl)imines Promoted by Stoichiometric Amounts of a Proline‐Derived β‐Amino Alcohol | Zendy

Yan Wenjin | Zendy; Mao Bin | Zendy; Zhu Shaoqun | Zendy; Jiang Xianxing | Zendy; Liu Zhongli | Zendy; Wang Rui | Zendy

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Asymmetric Addition of Terminal Alkynes to N ‐(Diphenylphosphinoyl)imines Promoted by Stoichiometric Amounts of a Proline‐Derived β‐Amino Alcohol

Author(s) -

Yan Wenjin,

Mao Bin,

Zhu Shaoqun,

Jiang Xianxing,

Liu Zhongli,

Wang Rui

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900342

Subject(s) - diethylzinc , chemistry , alkynylation , alcohol , proline , stoichiometry , optically active , organic chemistry , enantioselective synthesis , medicinal chemistry , amino acid , catalysis , biochemistry

A new synthetic methodology for the preparation of optically active propargylamines is described. The alkynylation of aromatic, heteroaromatic, aliphatic and α,β‐unsaturated N ‐(diphenylphosphinoyl)imines was investigated by using diethylzinc and a proline‐derived β‐amino alcohol. N ‐(Diphenylphosphinoyl)‐protected propargylic amines can be synthesized in high yields and with good to excellent enantioselectivities. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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