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Combinations of Alkyllithiums and Lithium Aminoalkoxides for Generation of Functional Pyridine Organometallics and Derivatives
Author(s) -
Gros Philippe C.,
Fort Yves
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900324
Subject(s) - chemistry , superbase , reagent , lithium (medication) , metalation , pyridine , combinatorial chemistry , carbanion , organic chemistry , catalysis , medicine , endocrinology
This account covers the current status of pyridine metallation with alkyllithium/lithium aminoalkoxide reagents and follows a previous review focusing on pioneering works on the n BuLi/LiDMAE reagent. An updated overview of the scope of metallation with this superbase is presented, together with the development of new reagents and synthetic applications based on selective lithiation methodology.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)