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Photoswitchable Unsymmetrical Ligand for DNA Hetero‐Mismatches
Author(s) -
Dohno Chikara,
Yamamoto Tsuyoshi,
Nakatani Kazuhiko
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900323
Subject(s) - chemistry , dna , ligand (biochemistry) , sequence (biology) , base pair , combinatorial chemistry , stereochemistry , computational biology , biochemistry , receptor , biology
Photoswitchable DNA‐binding ligands should be useful for controlling diverse biological functions involving DNA and reversible assembly of DNA‐based nanostructures. In work directed towards the development of photoswitchable ligands with various sequence specificities, we have elaborated an efficient synthesis of photoswitchable unsymmetrical ligands possessing pairs of different base recognition elements. A novel photoswitchable ligand incorporating an acylated aminonaphthyridine and an azaquinolone as its base recognition elements can bind to the CAG/CAG sequence in response to light stimuli.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)