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Facile Access to Fluorinated Aryl and Vinyl Ethers through Copper‐Catalysed Reaction of Fluoro Alcohols
Author(s) -
Vuluga Daniela,
Legros Julien,
Crousse Benoit,
BonnetDelpon Danièle
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900303
Subject(s) - chemistry , aryl , halide , copper , coupling reaction , organic chemistry , catalysis , reaction conditions , polymer chemistry , combinatorial chemistry , medicinal chemistry , alkyl
Fluorinated alcohols react with aryl and vinyl halides by copper‐catalysed cross‐coupling reactions to afford the corresponding ethers. With trifluoroethanol (TFE) the reaction proceeds with both iodides and bromides and a wide range of aromatic substituents are tolerated. When higher fluorinated homologues such as C 7 F 15 CH 2 OH were used, the corresponding products were obtained in good yields, thus offering an interesting entry to fluorous tagging. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)