Facile Access to Fluorinated Aryl and Vinyl Ethers through Copper‐Catalysed Reaction of Fluoro Alcohols | Zendy

Vuluga Daniela | Zendy; Legros Julien | Zendy; Crousse Benoit | Zendy; BonnetDelpon Danièle | Zendy

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Facile Access to Fluorinated Aryl and Vinyl Ethers through Copper‐Catalysed Reaction of Fluoro Alcohols

Author(s) -

Vuluga Daniela,

Legros Julien,

Crousse Benoit,

BonnetDelpon Danièle

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900303

Subject(s) - chemistry , aryl , halide , copper , coupling reaction , organic chemistry , catalysis , reaction conditions , polymer chemistry , combinatorial chemistry , medicinal chemistry , alkyl

Fluorinated alcohols react with aryl and vinyl halides by copper‐catalysed cross‐coupling reactions to afford the corresponding ethers. With trifluoroethanol (TFE) the reaction proceeds with both iodides and bromides and a wide range of aromatic substituents are tolerated. When higher fluorinated homologues such as C 7 F 15 CH 2 OH were used, the corresponding products were obtained in good yields, thus offering an interesting entry to fluorous tagging. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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