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Chemoenzymatic Synthesis of (Protected) Psymberic Acid
Author(s) -
Pietruszka Jörg,
Simon Robert Christian
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900292
Subject(s) - enantiopure drug , chemistry , acetal , natural product , total synthesis , stereochemistry , enantioselective synthesis , organic chemistry , combinatorial chemistry , catalysis
Two alternative approaches to the side‐chain of psymberin ( 1 ), psymberic acid ( 5 ), have been developed starting from either racemic or enantiopure acetal 6 . A five‐step chemoenzymatic route provided the PMB‐protected acid ( S , S )‐ 16 required for the coupling that should ultimately lead to the natural product 1 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)