Gold(I) Catalysis: Selective Synthesis of Six‐ or Seven‐Membered Heterocycles from Epoxy Alkynes | Zendy

Dai LunZhi | Zendy; Shi Min | Zendy

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Gold(I) Catalysis: Selective Synthesis of Six‐ or Seven‐Membered Heterocycles from Epoxy Alkynes

Author(s) -

Dai LunZhi,

Shi Min

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900210

Subject(s) - cycloisomerization , chemistry , ketone , intramolecular force , isomerization , lewis acids and bases , nucleophile , alkyne , catalysis , organic chemistry , hydroamination , medicinal chemistry

Gold(I)‐catalyzed intramolecular cycloisomerization of ketone‐substituted epoxides with alkynes to six‐ or seven‐membered heterocyclic compounds is firstly introduced in this paper. This procedure involves a cascade isomerization of the ketone‐substituted epoxides into 1,3‐diketones in the presence of a Lewis acid and subsequent gold(I)‐catalyzed selective intramolecular addition of an oxygen or a carbon nucleophile to the alkynes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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