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Catalytic Enantioselective Aldol Additions to Ketones
Author(s) -
Adachi Shinya,
Harada Toshiro
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900166
Subject(s) - aldol reaction , enantioselective synthesis , chemistry , steric effects , nucleophile , reactivity (psychology) , organic chemistry , ketone , catalysis , organocatalysis , medicine , alternative medicine , pathology
Enantioselective aldol addition to ketones has received growing attention since the resulting tertiary aldols are valuable building blocks for many biologically active compounds. Recently, several catalytic methodologies have been developed based on the activation of acceptor ketones and/or nucleophile enolates, overcoming problems associated with the lower reactivity and decreased steric discrimination of ketones compared to aldehydes. This microreview presents an overview of the progresses in the catalytic enantioselective aldol additions to ketones. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)