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Straightforward Synthesis of Chiral Hydroxy Isocyanides
Author(s) -
Bauer Michael,
Kazmaier Uli
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900109
Subject(s) - chemistry , oxazoline , isocyanide , combinatorial chemistry , organic chemistry , catalysis
Various types of hydroxy isocyanides have been prepared from the corresponding amino alcohols. These hydroxy isocyanides are interesting building blocks for multicomponent reactions and the synthesis of (hydroxyalkyl)oxazoline ligands. The isocyanides are susceptible to cyclization, giving rise to oxazolines. Therefore, they should be prepared freshly before use or be stored below –30 °C.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)