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Continuous‐Flow Microreactor Chemistry under High‐Temperature/Pressure Conditions
Author(s) -
Razzaq Tahseen,
Glasnov Toma N.,
Kappe C. Oliver
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900077
Subject(s) - microreactor , chemistry , supercritical fluid , boiling , flow chemistry , continuous flow , boiling point , bar (unit) , chemical engineering , solvent , flow (mathematics) , organic chemistry , catalysis , mechanics , meteorology , physics , engineering
High‐temperature organic synthesis can be performed under continuous‐flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 °C and 200 bar. Under these extreme experimental environments transformations normally performed in a high‐boiling solvent at reflux temperature – or under sealed‐vessel microwave conditions – can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)