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Thermal Effects in the Organocatalytic Asymmetric α‐Amination of Disubstituted Aldehydes with Azodicarboxylates: A High‐Temperature Organocatalysis (Eur. J. Org. Chem. 13/2008)
Author(s) -
Baumann Thomas,
Bächle Michael,
Hartmann Caroline,
Bräse Stefan
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200890030
Subject(s) - chemistry , amination , organocatalysis , adduct , stereoselectivity , yield (engineering) , catalysis , organic chemistry , microwave chemistry , microwave irradiation , enantioselective synthesis , medicinal chemistry , materials science , metallurgy
The cover picture shows the use of L ‐proline as an organocatalyst for the construction of nitrogen‐substituted quaternary carbon centres in the organocatalytic α‐amination of α,α‐disubstituted aldehydes. Since this reaction was found to be thermally accelerated, the use of microwave conditions resulted in a considerably reduced reaction time while both the yield and stereoselectivity were significantly increased. The beneficial effect of microwave irradiation may be associated with the quicker formation of intermediate dipolar adducts within the catalytic cycle. Details are presented in the article by S. Bräse et al. on p. 2207 ff. This picture has been provided by M. Bächle, one of the members in the author's group.