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Synthetic Strategies for Oseltamivir Phosphate (Eur. J. Org. Chem. 11/2008)
Author(s) -
Shibasaki Masakatsu,
Kanai Motomu
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200890024
Subject(s) - oseltamivir , chemistry , phosphate , environmentally friendly , combinatorial chemistry , covid-19 , organic chemistry , medicine , ecology , disease , infectious disease (medical specialty) , biology
The cover picture shows the chemical structure of oseltamivir phosphate (Tamiflu). Its representative starting materials and the asymmetric catalysts that provide its starting materials are also shown. Anybody can catch influenza. However, it is very scary, as it can be fatal. Oseltamivir phosphate is a potent antiinfluenza drug, that could protect humans from a possible influenza pandemic. The development of a synthetic route for oseltamivir phosphate that can satisfy its worldwide demand in a safe and environmentally friendly way is a great challenge today. In the Microreview by M. Shibasaki and M. Kanai on p. 1839 ff, synthetic strategies of oseltamivir are presented.