A Novel Galactosyltransferase Inhibitor with Diamino Sugar as a Pyrophosphate Mimic | Zendy

Mitsuhashi Nobuyuki | Zendy; Yuasa Hideya | Zendy

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A Novel Galactosyltransferase Inhibitor with Diamino Sugar as a Pyrophosphate Mimic

Author(s) -

Mitsuhashi Nobuyuki,

Yuasa Hideya

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200801285

Subject(s) - chemistry , galactosyltransferase , chelation , pyrophosphate , conjugate , sugar , stereochemistry , biochemistry , organic chemistry , enzyme , mathematical analysis , mathematics

Conjugates of 2,4‐diamino sugars and uridine have been synthesized as galactosyltransferase inhibitors. The relationship between inhibitory activity and the chelation abilility of the hinge‐like diamino sugar towards a metal ion was studied by NMR spectroscopy. One of the conjugates exhibited a moderate inhibition that ranks between those of UDP and UMP probably through the chelation of the hinge‐like diamino sugar to Mn II . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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