Premium
A Novel Galactosyltransferase Inhibitor with Diamino Sugar as a Pyrophosphate Mimic
Author(s) -
Mitsuhashi Nobuyuki,
Yuasa Hideya
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200801285
Subject(s) - chemistry , galactosyltransferase , chelation , pyrophosphate , conjugate , sugar , stereochemistry , biochemistry , organic chemistry , enzyme , mathematical analysis , mathematics
Conjugates of 2,4‐diamino sugars and uridine have been synthesized as galactosyltransferase inhibitors. The relationship between inhibitory activity and the chelation abilility of the hinge‐like diamino sugar towards a metal ion was studied by NMR spectroscopy. One of the conjugates exhibited a moderate inhibition that ranks between those of UDP and UMP probably through the chelation of the hinge‐like diamino sugar to Mn II . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)