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Synthesis of Indoles by Intermolecular Cyclization of Unfunctionalized Nitroarenes and Alkynes: One‐Step Synthesis of the Skeleton of Fluvastatin
Author(s) -
Ragaini Fabio,
Ventriglia Flavia,
Hagar Mohamed,
Fantauzzi Simone,
Cenini Sergio
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200801274
Subject(s) - chemistry , nitrobenzene , indole test , fluvastatin , intermolecular force , organic chemistry , selectivity , combinatorial chemistry , catalysis , molecule , medicine , simvastatin
The addition of Ru 3 (CO) 12 , dimethyl carbonate, or both to the reaction mixture improves the selectivity of the palladium/phenanthroline‐catalyzed reaction of nitroarenes, arylalkynes, and CO to give 3‐arylindoles. When 4‐fluorophenylacetylene and nitrobenzene are used as substrates, the indole skeleton of Fluvastatin and other pharmaceutically active compounds is obtained in one step.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)