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Click Multivalent Homogeneous Neoglycoconjugates – Synthesis and Evaluation of Their Binding Affinities
Author(s) -
PerezBalderas Francisco,
MoralesSanfrutos Julia,
HernandezMateo Fernando,
IsacGarcía Joaquín,
SantoyoGonzalez Francisco
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200801170
Subject(s) - chemistry , valency , linker , binding affinities , affinities , homogeneous , click chemistry , stereochemistry , concanavalin a , organic chemistry , combinatorial chemistry , biochemistry , philosophy , linguistics , receptor , physics , computer science , in vitro , thermodynamics , operating system
Abstract Mannose (α‐Man)‐containing neoglycoconjugates possessing aliphatic‐, aromatic‐, and carbohydrate‐centered architectures and differing in structural characteristics such as valency, topology, and nature of the linker have been synthesized using click chemistry that shows its value as an efficient and versatile methodology for accessing tailor‐made multivalent neoglycoconjugates. The binding behaviour of these glycomimics toward Concanavalin A (Con A) has been evaluated to determine the influence of the structural parameters. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)