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Chromogenic Chemosensors for N ‐Acetylaspartate Based on Chiral Ferrocene‐Bearing Thiourea Derivatives
Author(s) -
Qing GuangYan,
Sun TaoLei,
Wang Feng,
He YongBing,
Yang Xi
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800961
Subject(s) - thiourea , chemistry , ferrocene , titration , chromogenic , enantioselective synthesis , naked eye , combinatorial chemistry , polymer chemistry , medicinal chemistry , organic chemistry , electrochemistry , chromatography , catalysis , electrode , detection limit
A series of chiral ferrocene‐containing thiourea derivatives have been synthesized, and their enantioselective recognition properties were investigated by UV/Vis titration. Receptors 5a and 6a exhibit excellent chiral recognition abilities towards N ‐acetylaspartate. The differences in solution colour can be observed directly by the naked eye. The minimum energy structures of 5a and 6a were also obtained by theoretical DFT calculations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)