Premium
Asymmetric Hydrogenation of α‐Keto Phosphonates with Chiral Palladium Catalysts
Author(s) -
Goulioukitaliya S.,
Bondarenko Grigorii N.,
Bogdanov Alexei V.,
Gavrilov Konstantin N.,
Beletskaya Irina P.
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800943
Subject(s) - chemistry , palladium , catalysis , aryl , hydrogen , asymmetric hydrogenation , organic chemistry , carbon fibers , medicinal chemistry , atmospheric pressure , polymer chemistry , enantioselective synthesis , alkyl , materials science , composite number , composite material , oceanography , geology
Under atmospheric hydrogen pressure, a catalytic amount of palladium(II) trifluoroacetate and ( R )‐MeO‐BIPHEP in 2,2,2‐trifluoroethanol promoted the asymmetric hydrogenation of diisopropyl α‐keto phosphonates 1 to afford the corresponding α‐hydroxy phosphonates 2 in excellent yields and with a moderate enantioselectivities of up to 55 % ee . Racemic α‐aryl‐α‐hydroxy phosphonates can be prepared by using palladium on carbon as the catalyst. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom