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A Facile and Efficient Oxalyldihydrazide/Ketone‐Promoted Copper‐Catalyzed Amination of Aryl Halides in Water
Author(s) -
Zhu Xinhai,
Su Li,
Huang Liye,
Chen Gong,
Wang Jinlong,
Song Huacan,
Wan Yiqian
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800940
Subject(s) - chemistry , amination , aryl , catalysis , halide , ketone , copper , organic chemistry , coupling reaction , methyl vinyl ketone , combinatorial chemistry , polymer chemistry , alkyl
A novel three‐component catalyst CuO/oxalyldihydrazide/hexane‐2,5‐dione was a very convenient, economic, and effective catalytic system for the Ullmann‐type C–N coupling reaction in water. Both aryl bromides and aryl iodides could be aminated by a variety of amines even at room temperature or with heating to afford very good isolated yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)