Guanine‐Containing DNA Minor‐Groove Binders | Zendy

Pulido Daniel | Zendy; Sánchez Albert | Zendy; Robles Jordi | Zendy; Pedroso Enrique | Zendy; Grandas Anna | Zendy

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Guanine‐Containing DNA Minor‐Groove Binders

Author(s) -

Pulido Daniel,

Sánchez Albert,

Robles Jordi,

Pedroso Enrique,

Grandas Anna

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800892

Subject(s) - chemistry , minor groove , dna , guanine , duplex (building) , denaturation (fissile materials) , stereochemistry , thermal stability , combinatorial chemistry , biochemistry , organic chemistry , nucleotide , nuclear chemistry , gene

Solid‐phase procedures have been used to prepare six dipyrrole‐containing DNA ligands that combine (guanin‐9‐yl)acetyl, (guanin‐7‐yl)acetyl or acetyl moieties at the N‐terminal end and two lysines or a (dimethylamino)propyl group at the C terminus. Inspection of their DNA‐stabilizing properties by UV‐monitored thermal denaturation experiments showed that the ligand incorporating the (guanin‐9‐yl)acetyl group and the (dimethylamino)propyl tail had the highest duplex‐stabilizing effects.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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