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Guanine‐Containing DNA Minor‐Groove Binders
Author(s) -
Pulido Daniel,
Sánchez Albert,
Robles Jordi,
Pedroso Enrique,
Grandas Anna
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800892
Subject(s) - chemistry , minor groove , dna , guanine , duplex (building) , denaturation (fissile materials) , stereochemistry , thermal stability , combinatorial chemistry , biochemistry , organic chemistry , nucleotide , nuclear chemistry , gene
Abstract Solid‐phase procedures have been used to prepare six dipyrrole‐containing DNA ligands that combine (guanin‐9‐yl)acetyl, (guanin‐7‐yl)acetyl or acetyl moieties at the N‐terminal end and two lysines or a (dimethylamino)propyl group at the C terminus. Inspection of their DNA‐stabilizing properties by UV‐monitored thermal denaturation experiments showed that the ligand incorporating the (guanin‐9‐yl)acetyl group and the (dimethylamino)propyl tail had the highest duplex‐stabilizing effects.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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