Platinum‐Catalyzed Cyclization of  o ‐Alkynyl(oxo)benzenes with Alkenes by 1,2‐Migration of Benzene: Synthesis of 8‐Oxabicyclo[3.2.1]octane Derivatives | Zendy

Shu XingZhong | Zendy; Zhao ShuChun | Zendy; Ji KeGong | Zendy; Zheng ZhaoJing | Zendy; Liu XueYuan | Zendy; Liang YongMin | Zendy

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Platinum‐Catalyzed Cyclization of o ‐Alkynyl(oxo)benzenes with Alkenes by 1,2‐Migration of Benzene: Synthesis of 8‐Oxabicyclo[3.2.1]octane Derivatives

Author(s) -

Shu XingZhong,

Zhao ShuChun,

Ji KeGong,

Zheng ZhaoJing,

Liu XueYuan,

Liang YongMin

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800888

Subject(s) - chemistry , regioselectivity , octane , benzene , platinum , catalysis , bicyclic molecule , medicinal chemistry , organic chemistry

An interesting migration of the rigid structure of benzene was observed when propargylic esters were introduced to the cyclization chemistry of o ‐alkynyl(oxo)benzene. Various 8‐oxabicyclo[3.2.1]octane derivatives with many functional groups could be synthesized from this efficient approach catalyzed by platinum. The high stereo‐ and regioselectivity involved in this transformation was also attractive.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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