Structural Analysis of the Capsular Polysaccharide from  Acinetobacter lwoffii  F78 | Zendy

Hanuszkiewicz Anna | Zendy; Kaczyński Zbigniew | Zendy; Lindner Buko | Zendy; Goldmann Torsten | Zendy; Vollmer Ekkehard | Zendy; Debarry Jennifer | Zendy; Heine Holger | Zendy; Holst Otto | Zendy

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Structural Analysis of the Capsular Polysaccharide from Acinetobacter lwoffii F78

Author(s) -

Hanuszkiewicz Anna,

Kaczyński Zbigniew,

Lindner Buko,

Goldmann Torsten,

Vollmer Ekkehard,

Debarry Jennifer,

Heine Holger,

Holst Otto

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800887

Subject(s) - chemistry , polysaccharide , acetylation , nuclear magnetic resonance spectroscopy , mass spectrometry , stereochemistry , acinetobacter , bacteria , biochemistry , chromatography , genetics , biology , gene , antibiotics

The capsular polysaccharide from Acinetobacter lwoffii F78 was isolated and purified, and its structure was elucidated by chemical analyses, NMR spectroscopy, and mass spectrometry. The presence of a capsule on this bacterium was confirmed by transmission electron microscopy experiments, and the utilization of the antilipid A monoclonal antibody proved the nonendotoxin origin of the isolated material. The structure represents a novel nonbranched aminopolysaccharide with high heterogeneity of amino groups substituents: →3)‐α‐ L ‐FucNAc‐(1→3)‐β‐ D ‐QuiNR 1 4NR 2 ‐(1→4)‐β‐ L ‐GlcNR 3 3NR 4 A‐(1→, where R 1 = 3‐hydroxybutyric acid (3‐HBA) or N ‐acetylated alanine (AlaNAc), R 2 = AlaNAc or 3‐HBA, R 3 = acetyl or 3‐HBA, and R 4 = 3‐HBA or acetyl.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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