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First Total Synthesis of 14 C‐Labeled Procyanidin B2 – A Milestone Toward Understanding Cocoa Polyphenol Metabolism
Author(s) -
Viton Florian,
Landreau Cyrille,
Rustidge David,
Robert Fabien,
Williamson Gary,
Barron Denis
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800886
Subject(s) - chemistry , proanthocyanidin , polyphenol , milestone , metabolism , food science , stereochemistry , organic chemistry , biochemistry , antioxidant , archaeology , history
The idea that foods consumed for pure pleasure could provide health benefits received much recognition in the recent years. Among these foods, cocoa and dark chocolate are particularly rich in procyanidins, one of the major dietary families of polyphenols. We developed the first asymmetric total synthesis of procyanidin B2 and applied it to the preparation of a regioselectively radiolabeled 14 C‐analogue, which will be used to strengthen our knowledge on the metabolism of procyanidins.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)