Suzuki–Miyaura Coupling Reaction of Boronic Acids and Ethyl Glyoxylate: Synthetic Access to Mandelate Derivatives | Zendy

Francesco Irene Notar | Zendy; Wagner Alain | Zendy; Colobert Françoise | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Suzuki–Miyaura Coupling Reaction of Boronic Acids and Ethyl Glyoxylate: Synthetic Access to Mandelate Derivatives

Author(s) -

Francesco Irene Notar,

Wagner Alain,

Colobert Françoise

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800881

Subject(s) - chemistry , glyoxylate cycle , mandelic acid , catalysis , palladium , coupling reaction , organic chemistry , combinatorial chemistry , base (topology) , suzuki reaction , medicinal chemistry , enzyme , mathematical analysis , mathematics

The palladium‐catalyzed coupling reaction of arylboronicacids with ethyl glyoxylate provides a straightforward method for the synthesis of mandelic esters. Pd 2 (dba) 3 · CHCl 3 in combination with 2‐di‐ tert ‐butylphosphanylbiphenyl as the catalytic system and Cs 2 CO 3 as the base were used. The reaction tolerates a wide range of functionalized boronicacids. Mandelic esters were isolated in good‐to‐excellent yields with a variety of neutral, slightly electron‐rich, and slightly electron‐poor substituents.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research