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Oxime‐Based Synthesis of New Chromogenic and Fluorogenic Oligosaccharides
Author(s) -
Renaudet Olivier,
Dumy Pascal
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800855
Subject(s) - chromogenic , chemistry , oxime , anomer , oligosaccharide , carbohydrate , conjugated system , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , chromatography , polymer
A new simple approach for the synthesis of labelled oligosaccharides is described. Free synthetic carbohydrate recognition building blocks were conjugated with fluorogenic and chromogenic dyes under mild experimental conditions by using oxime ligation. The resulting oligosaccharide probes presenting well‐defined anomer configuration might find broad interests for recognition studies with a large panel of carbohydrate‐binding proteins. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)