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Cocatalytic Enzyme System for the Michael Addition Reaction of in‐situ‐Generated ortho ‐Quinones
Author(s) -
Witayakran Suteera,
Ragauskas Arthur J.
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800791
Subject(s) - chemistry , lipase , domino , reagent , nucleophile , catalysis , yield (engineering) , michael reaction , organic chemistry , enzyme catalysis , enzyme , materials science , metallurgy
A laccase‐lipase cocatalytic system was used to catalyze the domino reaction between catechols and nucleophilic reagents including 1,3‐dicarbonyl compounds and aromatic amines in aqueous medium at room temperature. Lipase acted as a catalyst for Michael addition step, and also enhanced the overall yield of the final products. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)