Premium
TMSOTf‐Promoted Addition of Alkynes to Aldehydes: A Novel Synthesis of Chroman‐4‐ones
Author(s) -
Park Ji Yeon,
Ullapu Punna Reddy,
Choo Hyunah,
Lee Jae Kyun,
Min SunJoon,
Pae Ae Nim,
Kim Youseung,
Baek DuJong,
Cho Yong Seo
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800782
Subject(s) - chemistry , organic chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry
A novel synthetic method to prepare chalcones 2 and chroman‐4‐ones 3 by TMSOTf‐promoted addition of alkynes 1 to various aldehydes has been developed. The ratios of chalcones 2 , chroman‐4‐ones 3 and hydrated products 4 varied depending upon the substituents R ( n Bu, phenyl, H and TMS) on the alkynes 1 . We also describe the transformation of the chalcones 2 to the corresponding chroman‐4‐ones 3 under basic conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom