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Synthesis of 1‐Amino‐1 H ‐indole‐3‐carboxylates by Copper(I)‐Catalyzed Intramolecular Amination of Aryl Bromides
Author(s) -
Melkonyan Ferdinand,
Topolyan Artyom,
Yurovskaya Marina,
Karchava Alexander
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800777
Subject(s) - chemistry , amination , intramolecular force , indole test , catalysis , copper , aryl , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , alkyl
A simple route to various N ‐substituted 1‐amino‐1 H ‐indole‐3‐carboxylates by use of copper(I)‐catalyzed intramolecular N ‐arylation has been established. For the preparation of N ‐monosubstituted and N ‐unsubstituted derivatives, the cyclization of Boc‐protected enehydrazines and subsequent deprotection were applied. Furthermore, 1‐alkoxyindole‐3‐carboxylates can be synthesized by use of the same protocol(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)