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Synthesis of Hybrids of D ‐Glucose and D ‐Galactose with Pyrrolidine‐Based Iminosugars as Glycosidase Inhibitors
Author(s) -
Doddi Venkata Ramana,
Kokatla Hari Prasad,
Pal A. P. John,
Basak Ranjan K.,
Vankar Yashwant D.
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800770
Subject(s) - iminosugar , chemistry , pyrrolidine , xylitol , glycoside hydrolase , sugar , galactose , glycal , stereochemistry , biochemistry , enzyme , stereoselectivity , catalysis , fermentation
Sugar–iminosugar hybrid molecules made up of D ‐glucose and D ‐galactose with pyrrolidine‐based iminosugars, viz. 1,4‐dideoxy‐1,4‐imino‐ L ‐xylitol and 1,4‐dideoxy‐1,4‐imino‐ L ‐lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)