Synthesis of Hybrids of  D ‐Glucose and  D ‐Galactose with Pyrrolidine‐Based Iminosugars as Glycosidase Inhibitors | Zendy

Doddi Venkata Ramana | Zendy; Kokatla Hari Prasad | Zendy; Pal A. P. John | Zendy; Basak Ranjan K. | Zendy; Vankar Yashwant D. | Zendy

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Synthesis of Hybrids of D ‐Glucose and D ‐Galactose with Pyrrolidine‐Based Iminosugars as Glycosidase Inhibitors

Author(s) -

Doddi Venkata Ramana,

Kokatla Hari Prasad,

Pal A. P. John,

Basak Ranjan K.,

Vankar Yashwant D.

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800770

Subject(s) - iminosugar , chemistry , pyrrolidine , xylitol , glycoside hydrolase , sugar , galactose , glycal , stereochemistry , biochemistry , enzyme , stereoselectivity , catalysis , fermentation

Sugar–iminosugar hybrid molecules made up of D ‐glucose and D ‐galactose with pyrrolidine‐based iminosugars, viz. 1,4‐dideoxy‐1,4‐imino‐ L ‐xylitol and 1,4‐dideoxy‐1,4‐imino‐ L ‐lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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