Gold(I) Iodide Catalyzed Sonogashira Reactions | Zendy

Li Pinhua | Zendy; Wang Lei | Zendy; Wang Min | Zendy; You Feng | Zendy

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Gold(I) Iodide Catalyzed Sonogashira Reactions

Author(s) -

Li Pinhua,

Wang Lei,

Wang Min,

You Feng

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800765

Subject(s) - sonogashira coupling , chemistry , iodide , aryl , catalysis , toluene , coupling reaction , organic chemistry , medicinal chemistry , combinatorial chemistry , palladium , alkyl

Gold(I) iodide catalyzed Sonogashira reactions have been developed. Terminal alkynes reacted with aryl iodides and bromides smoothly in the presence of AuI (1 mol‐%) and dppf (1 mol‐%) in toluene to generate the corresponding cross‐coupling products in good to excellent yields. Furthermore, aromatic terminal alkynes could also react with 2‐iodoaniline to form substituted indoles in excellent yields through a coupling–cyclization reaction sequence under the present reaction conditions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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