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Gold(I) Iodide Catalyzed Sonogashira Reactions
Author(s) -
Li Pinhua,
Wang Lei,
Wang Min,
You Feng
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800765
Subject(s) - sonogashira coupling , chemistry , iodide , aryl , catalysis , toluene , coupling reaction , organic chemistry , medicinal chemistry , combinatorial chemistry , palladium , alkyl
Abstract Gold(I) iodide catalyzed Sonogashira reactions have been developed. Terminal alkynes reacted with aryl iodides and bromides smoothly in the presence of AuI (1 mol‐%) and dppf (1 mol‐%) in toluene to generate the corresponding cross‐coupling products in good to excellent yields. Furthermore, aromatic terminal alkynes could also react with 2‐iodoaniline to form substituted indoles in excellent yields through a coupling–cyclization reaction sequence under the present reaction conditions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)