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Catalytic Enantioselective α‐Oxysulfonylation of Ketones Mediated by Iodoarenes
Author(s) -
Altermann Sabine M.,
Richardson Robert D.,
Page T. Keri,
Schmidt Ruth K.,
Holland Edward,
Mohammed Umal,
Paradine Shauna M.,
French Andrew N.,
Richter Christine,
Bahar A. Masih,
Witulski Bernhard,
Wirth Thomas
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800741
Subject(s) - enantioselective synthesis , chemistry , hypervalent molecule , organocatalysis , catalysis , reagent , yield (engineering) , organic chemistry , stoichiometry , combinatorial chemistry , materials science , metallurgy
The α‐oxysulfonylation of ketones catalysed by enantioenriched iodoarenes using m CPBA as stoichiometric oxidant is reported to give useful synthetic intermediates in good yield and modest enantioselectivity. We believe this to be the first report of an enantioselective organocatalytic reaction involving hypervalent iodine reagents which should open up a new field for enantioselective organocatalysis of oxidation reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)