Premium
An Overview of Syntheses of Apogalanthamine Analogues and 7‐Aza Derivatives of Steganacin and Steganone
Author(s) -
Appukkuttan Prasad,
Van der Eycken Erik
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800699
Subject(s) - chemistry , amaryllidaceae alkaloids , total synthesis , stereochemistry , combinatorial chemistry , nanotechnology , alkaloid , materials science
A concise and critical overview of the developments in the synthesis of apogalanthamine analogues and steganacin and steganone 7‐aza analogues over the last four decades is presented. These amaryllidaceae alkaloid analogues bear a 5,6,7,8‐tetrahydrodibenz[ c , e ]azocine skeleton, and are well known for their diverse and potent biological activities. This microreview will briefly glance over the history and early developments in the field at the beginning, and will, in the latter parts, concentrate on the recent synthetic developments in the synthesis of the title molecules. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)