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Synthesis of α‐Amino Acids by Umpolung of Weinreb Amide Enolates
Author(s) -
Hirner Sebastian,
Kirchner Donata K.,
Somfai Peter
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800683
Subject(s) - umpolung , chemistry , amino acid , glycine , amide , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , biochemistry , nucleophile
An efficient and diastereoselective synthesis of α‐amino acids from readily available starting materials has been developed. The key feature of this reaction is an umpolung of a glycine‐derived enolate, providing an alternative approach for the synthesis of α‐amino acids. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)