Efficient and Flexible Solid‐Phase Synthesis of  N ‐Hydroxypolyamine Derivatives | Zendy

Méret Michaël | Zendy; Bienz Stefan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Efficient and Flexible Solid‐Phase Synthesis of N ‐Hydroxypolyamine Derivatives

Author(s) -

Méret Michaël,

Bienz Stefan

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800677

Subject(s) - chemistry , polyamine , linker , solid phase synthesis , cleavage (geology) , bromide , nucleophile , combinatorial chemistry , nucleophilic substitution , polymer chemistry , organic chemistry , biochemistry , catalysis , peptide , geotechnical engineering , fracture (geology) , computer science , engineering , operating system

Orthogonally protected, N ‐hydroxylated, linear tri‐ and tetra‐amines were efficiently synthesised on Merrifield resin, which was modified with a phenethyl bromide linker. The polyamine frameworks were convergently prepared “from the centre” with reductive aminations and nucleophilic substitutions to elongate the polyamine backbone. The required N ‐hydroxy groups were introduced during the cleavage of the polyamine derivatives from the resin through Cope elimination.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research