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Grecoketides A and B: New Naphthoquinones from Streptomyces sp. Acta 1362
Author(s) -
Paululat Thomas,
Katsifas Efstathios A.,
Karagouni Amalia D.,
Fiedler HansPeter
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800676
Subject(s) - chemistry , sugar , stereochemistry , streptomyces , biosynthesis , organic chemistry , bacteria , genetics , biology , enzyme
Two novel naphthoquinones were produced by the streptomycete Acta 1362. It was determined by HPLC/diode‐array screening that freshly isolated actinomycete strains from selected European ecosystems produce new compounds. Grecoketides A and B were isolated and their structures determined. Both compounds have the same aglycon grecoketidone with a sugar side‐chain that differs in one of the two attached sugar units. Moreover, the biosynthesis of grecoketidone was studied by feeding singly and fully labelled acetate. The hexaketide formed is cyclized after s‐mode folding. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)