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Salt‐Free Synthesis of Tertiary Amines by Ruthenium‐Catalyzed Amination of Alcohols
Author(s) -
Tillack Annegret,
Hollmann Dirk,
Mevius Kathleen,
Michalik Dirk,
Bähn Sebastian,
Beller Matthias
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800671
Subject(s) - chemistry , amination , ruthenium , catalysis , yield (engineering) , alkylation , organic chemistry , reductive amination , cyclic amines , salt (chemistry) , pyrrole , materials science , metallurgy
The amination of secondary alcohols to give tertiary amines in the presence of different in situ generated ruthenium catalysts has been investigated in detail. By applying a combination of [Ru 3 (CO) 12 ] and N ‐phenyl‐2‐(dicyclohexylphosphanyl)pyrrole as the catalyst, cyclic amines can be alkylated with different alcohols in high yield, whereas aliphatic amines gave transalkylation side products.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)