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Nano‐CuO‐Catalyzed Ullmann Coupling of Phenols with Aryl Halides under Ligand‐Free Conditions
Author(s) -
Zhang Jintang,
Zhang Zuhui,
Wang Ye,
Zheng Xiaoqi,
Wang Zhiyong
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800637
Subject(s) - chemistry , catalysis , aryl , halide , phenols , ligand (biochemistry) , coupling reaction , copper , organic chemistry , solvent , combinatorial chemistry , biochemistry , alkyl , receptor
Nano copper oxide has been found to be a highly efficient and reusable catalyst for the C–O cross‐coupling of phenols with aryl halides under ligand‐free conditions. With DMSO as solvent, Cs 2 CO 3 and KOH are suitable bases for the cross‐coupling reactions with phenyl iodides and bromides, respectively. Diaryl ethers with different substituted groups can be synthesized in moderate‐to‐good yields. The catalyst can be recycled at least five times without obvious loss in catalytic activity.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)