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Diastereoselective Synthesis of Heteroaromatic Glycine Derivatives
Author(s) -
Andreassen Trygve,
Hansen LarsKristian,
Gautun Odd R.
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800622
Subject(s) - chemistry , diastereomer , glycine , yield (engineering) , optically active , absolute configuration , stereochemistry , organic chemistry , medicinal chemistry , amino acid , biochemistry , materials science , metallurgy
A TMSOTf promoted addition of an N ‐ tert ‐butanesulfinyl α‐imino ester to five‐membered aromatic heterocycles furnishes optically active heteroaromatic glycine derivatives with moderate‐to‐good yield in diastereomeric ratios up to 99 %. The absolute configuration of two of the addition products were solved by X‐ray analysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)