Diastereoselective Synthesis of Heteroaromatic Glycine Derivatives | Zendy

Andreassen Trygve | Zendy; Hansen LarsKristian | Zendy; Gautun Odd R. | Zendy

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Diastereoselective Synthesis of Heteroaromatic Glycine Derivatives

Author(s) -

Andreassen Trygve,

Hansen LarsKristian,

Gautun Odd R.

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800622

Subject(s) - chemistry , diastereomer , glycine , yield (engineering) , optically active , absolute configuration , stereochemistry , organic chemistry , medicinal chemistry , amino acid , biochemistry , materials science , metallurgy

A TMSOTf promoted addition of an N ‐ tert ‐butanesulfinyl α‐imino ester to five‐membered aromatic heterocycles furnishes optically active heteroaromatic glycine derivatives with moderate‐to‐good yield in diastereomeric ratios up to 99 %. The absolute configuration of two of the addition products were solved by X‐ray analysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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