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Synthesis of the L‐Acid (C1–C18) Fragment of Pamamycin‐593 and De‐ N ‐methylpamamycin‐579
Author(s) -
Miura Ayako,
Takigawa Shinya,
Furuya Yukito,
Yokoo Yusuke,
Kuwahara Shigefumi,
Kiyota Hiromasa
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800600
Subject(s) - chemistry , acetylide , fragment (logic) , stereochemistry , aldehyde , nucleophile , nucleophilic addition , organic chemistry , catalysis , computer science , programming language
The L‐acid (C1–C18) fragment of pamamycin‐593 and de‐ N ‐methylpamamycin‐579, strong aerial mycelium‐inducers of Streptomyces alboniger , was synthesized using a cis ‐selective iodoetherification and a nucleophilic addition of a cerium acetylide to an aldehyde as the key steps. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)