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Taxpropellane: A Novel Taxane with an Unprecedented Polycyclic Skeleton from the Needles of Taxus canadensis
Author(s) -
Zhang ManLi,
Dong Mei,
Huo ChangHong,
Li LiGeng,
Sauriol Françoise,
Shi QingWen,
Gu YuCheng,
Makabe Hidefumi,
Kiyota Hiromasa
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800587
Subject(s) - taxane , chemistry , propellane , stereochemistry , ring (chemistry) , cycloaddition , skeleton (computer programming) , diterpene , organic chemistry , bicyclic molecule , catalysis , medicine , cancer , breast cancer , computer science , programming language
Abstract Taxpropellane, the first example of a taxane with an unprecedented 6/5/5/6/4/5‐membered ring hexacyclic skeleton ([3.3.2]propellane), was isolated from the needles of Taxus canadensis . This compound would be derived from a normal 6/8/6 taxane by a [2+2] cycloaddition reaction between the 3,4‐ and 11,12‐double bonds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)