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Palladium‐Catalyzed Asymmetric Conjugate Addition of Aryl–Metal Species
Author(s) -
Gutnov Andrey
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800541
Subject(s) - chemistry , palladium , aryl , catalysis , reagent , combinatorial chemistry , rhodium , conjugate , michael reaction , organic chemistry , mathematical analysis , alkyl , mathematics
The objective of this review is to summarize developments in the recently discovered area of palladium‐catalyzed asymmetric Michael additions of organometallic reagents to activated electron‐deficient olefins in its practical and theoretical aspects. The methodology has been rapidly developed in the last five years as a useful alternative approach to complement the already existing copper‐ and rhodium‐catalyzed variants, especially in the area of asymmetric aryl transfer to typical Michael acceptors. Although very difficult to control because of numerous side reactions, this palladium catalysis is very promising for applications both in academia and in industry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)