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TBD‐Catalyzed Direct 5‐ and 6‐ enolexo Aldolization of Ketoaldehydes
Author(s) -
Ghobril Cynthia,
Sabot Cyrille,
Mioskowski Charles,
Baati Rachid
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800539
Subject(s) - chemistry , intramolecular force , catalysis , combinatorial chemistry , organic chemistry
Treatment of unfunctionalized acyclic ketoaldehydes with a catalytic amount of 1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene induces a direct intramolecular 5‐ and 6‐ enolexo aldolization, furnishing 2‐ketocyclopentanols and 2‐ketocyclohexanols in good‐to‐excellent yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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