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First Example of Organocatalysis by Polystyrene‐Supported PAMAM Dendrimers: Highly Efficient and Reusable Catalyst for Knoevenagel Condensations
Author(s) -
Krishnan G. Rajesh,
Sreekumar Krishnapillai
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800516
Subject(s) - knoevenagel condensation , chemistry , dendrimer , catalysis , organocatalysis , polystyrene , poly(amidoamine) , amidoamine , methylene , organic chemistry , polymer chemistry , combinatorial chemistry , polymer , enantioselective synthesis
This paper describes the first use of polystyrene‐supported poly(amidoamine) (PAMAM) dendrimers as heterogeneous basic organocatalysts for carbon–carbon bond formation. Polystyrene‐supported PAMAM dendrimers of first, second and third generations have been used as reusable base catalysts in Knoevenagel condensations of carbonyl compounds with active methylene compounds. The reactions proceed in short periods of time and with 100 % selectivity. This novel catalyst eliminates the use of aromatic and halogenated solvents, as well as complex purification processes. The catalysts can be recycled ten times.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)