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Organocatalytic Three‐Component Reactions of Pyruvate, Aldehyde and Aniline by Hydrogen‐Bonding Catalysts
Author(s) -
Li Xin,
Deng Hui,
Luo Sanzhong,
Cheng JinPei
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800491
Subject(s) - chemistry , catalysis , aniline , aldehyde , organic chemistry , phosphoric acid , organocatalysis , hydrogen bond , combinatorial chemistry , enantioselective synthesis , molecule
Hydrogen‐bonding catalysts have been found to catalyze one‐pot three‐component reactions of pyruvate, anilines and aldehydes to afford versatile 3‐amino‐1,5‐dihydro‐2 H ‐pyrrol‐2‐ones in high yields. Both, thioureas and phosphoric acids are viable catalysts for these reactions and have comparable activity. The corresponding chiral thioureas and phosphoric acids have also been used in these three‐component reactions to give pyrrol‐2‐ones in high yields and with moderate enantioselectivities.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)