Premium
Alkynyl Halides in Ruthenium(II)‐Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes
Author(s) -
Allen Anna,
Villeneuve Karine,
Cockburn Neil,
Fatila Elisabeth,
Riddell Nicole,
Tam William
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800424
Subject(s) - chemistry , cycloaddition , bicyclic molecule , alkyne , moiety , halide , ruthenium , reactivity (psychology) , catalysis , medicinal chemistry , organic chemistry , pathology , medicine , alternative medicine
Ru‐catalyzed [2+2] cycloadditions between bicyclic alkenes and alkynyl halides were found to occur in moderate to good yields. The presence of the halide moiety greatly enhances the reactivity of the alkyne component in the cycloaddition and can be transformed into a variety of products that are difficult or impossible to obtain by direct cycloaddition. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)