Multicomponent Domino Reaction Promoted by Mg(ClO 4 ) 2 : Highly Efficient Access to Functionalized 1,4‐Dihydropyridines | Zendy

Bartoli Giuseppe | Zendy; Bosco Marcella | Zendy; Galzerano Patrizia | Zendy; Giri Roberto | Zendy; Mazzanti Andrea | Zendy; Melchiorre Paolo | Zendy; Sambri Letizia | Zendy

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Multicomponent Domino Reaction Promoted by Mg(ClO 4 ) 2 : Highly Efficient Access to Functionalized 1,4‐Dihydropyridines

Author(s) -

Bartoli Giuseppe,

Bosco Marcella,

Galzerano Patrizia,

Giri Roberto,

Mazzanti Andrea,

Melchiorre Paolo,

Sambri Letizia

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800422

Subject(s) - chemistry , domino , reaction conditions , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis

An efficient, one‐pot multicomponent synthetic protocol toward substituted 1,4‐dihydropyridines from aromatic amines, β‐keto derivatives, and ethyl propiolate mediated by Mg(ClO 4 ) 2 is described. When ortho ‐ or meta ‐substituted arylamines are used, two conformational isomers are generated. An NMR spectroscopic study of the energy barrier involved in the interconversion of the isomers is reported.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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