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Phosphotungstic Acid Catalyzed Amidation of Alcohols
Author(s) -
Wang GuanWu,
Shen YeBing,
Wu XueLiang
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800413
Subject(s) - phosphotungstic acid , chemistry , catalysis , allylic rearrangement , benzamide , amine gas treating , organic chemistry , nucleophilic substitution , nucleophile , combinatorial chemistry
Mild nucleophilic substitution reactions of benzhydrylic, benzylic, allylic, and simple aliphatic alcohols with sulfonamides, benzamide, and 4‐nitroaniline in the presence of 12‐phosphotungstic acid as an efficient, eco‐friendly, cheap, and air‐ and moisture‐tolerant catalyst for the construction of C–N bonds has been investigated. The amine derivatives were obtained in good yields (up to 98 %). The reusable nature of the 12‐phosphotungstic acid makes this protocol more attractive.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)