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The Use of a Bifunctional Copper Catalyst in the Cross‐Coupling Reactions of Aryl and Heteroaryl Halides with Terminal Alkynes
Author(s) -
Wu Minyan,
Mao Jincheng,
Guo Jun,
Ji Shunjun
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800394
Subject(s) - chemistry , bifunctional , halide , aryl , catalysis , alkynylation , copper , coupling reaction , combinatorial chemistry , terminal (telecommunication) , ligand (biochemistry) , bifunctional catalyst , coupling (piping) , polymer chemistry , medicinal chemistry , organic chemistry , mechanical engineering , telecommunications , biochemistry , alkyl , receptor , computer science , engineering
Copper‐catalyzed cross‐coupling reactions of aryl halides and heteroaryl halides with terminal alkynes were carried out in DMF at 110–130 °C to provide the corresponding coupling products in satisfactory‐to‐good yields by using inexpensive 8‐hydoxyquinoline as the ligand. Noteworthy is that the bifunctional copper catalyst was successfully applied in this alkynylation reaction for the first time.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)