The Thread & Cut Method: Syntheses of Molecular Knot Precursors | Zendy

Fenlon Edward E. | Zendy; Ito Brandon R. | Zendy

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The Thread & Cut Method: Syntheses of Molecular Knot Precursors

Author(s) -

Fenlon Edward E.,

Ito Brandon R.

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200800387

Subject(s) - chemistry , alkyne , knot (papermaking) , click chemistry , azide , combinatorial chemistry , stereochemistry , organic chemistry , chemical engineering , catalysis , engineering

A novel approach to molecular knots is described. This method may allow access to smaller and more complex knots. Two knot precursors, 1a and 1b , are efficiently prepared in overall yields of 9.6 % and 8.7 %, respectively. The convergent six‐step syntheses utilize Fréchet‐type etherifications, alkyne/azide click cycloadditions, and bis‐macrolactonizations.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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